ATOR-1144 is a first-in-class bispecific tumor-localized antibody targeting the checkpoint inhibitor CTLA-4 and the co-stimulatory receptor GITR.
The bispecific antibody ATOR-1144 is a dual immune activator targeting CTLA-4 and GITR. It works through several pathways, including activation of T cells, depletion of regulatory T cells (Tregs) and activation of NK (natural killer) cells, for enhanced tumor cell killing. Based on its mode of action, ATOR-1144 may be suitable for the treatment of solid tumors as well as hematological cancers.
ATOR-1144 is a bispecific antibody drug candidate targeting both CTLA-4 and GITR. It is a combination of a GITR specific antibody isolated from ALLIGATOR-GOLD®, while the CTLA-4 part was developed by FIND® optimization of CD86, a natural CTLA-4 ligand. GITR (Glucocorticoid-Induced TNFR family Related) is a member of the TNFR superfamily (TNFRSF) that is expressed in different cell types, including T lymphocytes and NK cells.