Vetenskapliga publikationer - Alligator Bioscience

Mitazalimab, a potent CD40 agonist in combination with chemotherapy redirects and activates tumor infiltrating myeloid cells

Karin Enell Smith, Mia Thagesson, Anneli Nilsson, Doreen Werchau, and Peter Ellmark, Poster AACR, April 13, 2022

ATOR-1017, a second generation 4-1BB antibody with potential to enhance efficacy of PD-1 therapies

Karin Enell Smith, Anneli Nilsson, and Peter Ellmark, Poster SITC, November 12, 2021

Neo-X-Prime™ bispecific antibodies targeting CD40 and tumor antigens promote cross-presentation of tumor exosome-derived neoantigens and induce a superior anti-tumor response

Karin Hägerbrand, Laura Varas, Mattias Levin, Laura von Schantz, Anna Säll, Adnan Deronic, Anette Sundstedt, Lill Ljung, Karin Barchan, Doreen Werchau, Anna Rosén, Maria Johansson, Barnabas Nyesiga, Eva Lindqvist, Mia Thagesson and Peter Ellmark, Poster SITC, November 12, 2021

OPTIMIZE-1, an open-label phase 1b/2 study assessing the safety and efficacy of mitazalimab in combination with chemotherapy in patients with metastatic pancreatic ductal adenocarcinoma

Yago Pico de Coaña, Karin Enell Smith, Anette Fält, Maria Flärdh, Peter Ellmark, Philippe Cassier, Jean-Luc van Laethem and Malin Carlsson, Poster SITC, November 12, 2021

ALG.APV-527: A 5T4 tumor directed bispecific approach utilizing ADAPTIRTM technology designed for conditional 4-1BB T cell/NK agonism against solid tumors

Michelle H. Nelson, Anette Sundstedt, Yago Pico de Coaña, Ashly Lucas, Anneli Nilsson, Lill Ljung, Allison Chunyk, Lena Schultz, Catherine McMahan, Jane Gross, Sara Frizell, Hilario Ramos and Peter Ellmark, Poster SITC, November 12, 2021

Rationale and clinical development of CD40 agonistic antibodies for cancer immunotherapy

Karin Enell Smith, Adnan Deronic, Karin Hägerbrand, Per Norlén and Peter Ellmark, Expert Opinion on Biological Therapy, June 17, 2021

A first-in-human, multicenter, open-label, phase 1 study of ATOR-1017, a 4-1BB antibody, in patients with advanced solid malignancies

Gustav J. Ullenhag, Jeffrey Yachnin, Ana Carneiro, Lena Schultz, Peter Ellmark, Karin Enell Smith, Tina Hjorth, Tova Landström, Poster ASCO, June 7, 2021

Mitazalimab, a potent CD40 agonist with potential for combination with chemotherapy

Adnan Deronic, Mia Thagesson, Anneli Nilsson, Peter Ellmark, Anette Fält, Charlotte Russell and Karin Enell Smith, Poster AACR, April 10, 2021

The human anti‑CD40 agonist antibody mitazalimab (ADC‑1013; JNJ‑64457107) activates antigen‑presenting cells, improves expansion of antigen‑specific T cells, and enhances anti‑tumor efficacy of a model cancer vaccine in vivo

Adnan Deronic, Anneli Nilsson, Mia Thagesson, Doreen Werchau, Karin Enell Smith and Peter Ellmark, Cancer Immunology Immunotherapy, 5 May, 2021

A bispecific antibody targeting CD40 and EpCAM induces superior anti-tumor effects compared to the combination of monospecific antibodies

Karin Hägerbrand, Mattias Levin, Laura von Schantz, Adnan Deronic, Laura Varas, Anna Säll, Karin Barchan, Doreen Werchau, Lill Ljung, Mia Thagesson, Anna Rosén, Christina Sakellariou, Malin Lindstedt and Peter Ellmark, Poster SITC November 9, 2020

Potent Tumor-Directed T-cell Activation and Tumor Inhibition Induced by a 4-1BB x 5T4 ADAPTIR™ Bispecific Antibody

Michelle Nelson, Robert Miller, Anneli Nilsson, Lill Ljung, Allison Chunyk, Catherine McMahan, David Bienvenue, Maria Askmyr, Gabriela Hernandez-Hoyos and Sara Fritzell, Poster SITC November 9, 2020

Safety and pharmacodynamic activity of ATOR-1015, a CTLA-4 x OX40 bispecific antibody, in a phase 1 dose escalation study of patients with advanced solid malignancies

Jeffrey Yachnin, Gustav J. Ullenhag, Ana Carneiro, Dorte Nielsen, Kristoffer Staal Rohrberg, Anne Månsson Kvarnhammar, Lena Schultz, Erika Bågeman, Camilla Wennersten and Charlotte Astrid Russell, Poster SITC November 9, 2020

Mitazalimab – a CD40 agonist to unleash CD40 in immuno-oncology

Peter Ellmark, PhD, Ass. Prof, VP Discovery Alligator Bioscience, World Immunotherapy Congress, November 5, 2020

A first-in-human phase 1 study in patients with advanced and/or refractory solid malignancies to evaluate the safety of ATOR-1015, a CTLA-4 x OX40 bispecific antibody

Jeffrey Yachnin , Gustav J. Ullenhag , Ana Carneiro , Dorte Nielsen , Kristoffer Staal Rohrberg, Anne Månsson Kvarnhammar, Lena Schultz, Erika Bågeman, Camilla Wennersten, Charlotte Astrid Russell, Poster ASCO May 20, 2020

A first-in-human phase 1 study in patients with advanced and/or refractory solid malignancies to evaluate the safety of ATOR-1015, a CTLA-4 x OX40 bispecific antibody

Jeffrey Yachnin, Gustav J. Ullenhag, Ana Carneiro, Dorte L. Nielsen, Kristoffer Staal Rohrberg, Anne Månsson Kvarnhammar, Erika Bågeman, Camilla S. Wennersten, Charlotte Astrid Russell, Video presentation April 27, 2020 at AACR Virtual Annual Meeting, nås via följande länk, https://www.youtube.com/channel/UCblfdPkN76f_NTD0qBtJlBg/videos

ATOR-1017, a 4-1BB Antibody Developed for Tumor-Directed Immunotherapy of Cancer

D Werchau, A Rosén, M Eriksson, S Järnum, C Furebring and K Enell Smith, Poster SITC November 9, 2019

Potent Tumor-Directed T cell Activation and Tumor Inhibition Induced by a 4-1BB x 5T4 ADAPTIR™ Bispecific Antibody

M Nelson, R Miller, R Bader, D Werchau, A Nilsson, L Ljung, A Deronic, A Chunyk, L Schultz, C McMahan, D Bienvenue, A Dahlman, S Fritzell, M Askmyr, G Hernandez-Hoyos, Poster SITC November 9, 2019

4224, a tumor exosome-transforming antibody targeting CD40 and EpCAM, induces superior anti-tumor effects compared to monospecific CD40 antibody

Adnan Deronic, Laura von Schantz, Mia Thagesson, Kristine Smedenfors, Christina Sakellariou, Lill Ljung, Fredrika Carlsson, Doreen Werchau, Malin Lindstedt, Peter Ellmark, Karin Hägerbrand, CICON, 26 september 2019

A first-in-human, multicenter, open-label, phase 1 study in patients with advanced and/or refractory solid malignancies to evaluate the safety of intravenously administered ATOR-1015

Jeffrey Yachnin, Gustav J Ullenhag, Ana Carneiro, Dorte Nielsen, Kristoffer Staal Rohrberg, Anne Månsson Kvarnhammar, Anna Dahlman, Erika Bågeman, Camilla Wennersten , Charlotte Astrid Russell., Poster ASCO 1 juni 2019,

RUBY TM – A novel recombinant universal bispecific antibody format for generation of bsAb with outstanding stability, manufacturability and shorter development timelines

A Säll, M Levin, B Nyesiga, M Mårtensson, S Fritzell, K Hägerbrand, C Furebring, L von Schantz, Poster PEGS 11 April 2019

ATOR-1144 is a tumor-directed CTLA-4 x GITR bispecific antibody that acts by depleting Tregs and activating effector T cells and NK cells

S Fritzell, M Levin, A Dahlman, I Åberg, M Johansson, M Winnerstam, K Enell Smith, P Ellmark, C Furebring, P Norlén, A Månsson Kvarnhammar, AACR Annual Meeting April 2, 2019

Preclinical safety and efficacy of a tumor-directed T cell activating 4-1BB x 5T4 ADAPTIR™ bispecific antibody

A Dahlman, M Nelson, J Bannink, Starrla Johnson, D Werchau, A Nilsson, L Ljung, G Blahnik-Fagan, R Bader, P Ellmark, M Askmyr, G Hernandez-Hoyos, C McMahan, S Fritzell, AACR 1 april 2019,

The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation

Anne Månsson Kvarnhammar, Niina Veitonmäki, Karin Hägerbrand, Mia Thagesson, Doreen Werchau, Kristine Smedenfors, Anna Dahlman, Anna Rosén, Maria Johansson, Ida Åberg, Per Norlén, Christina Furebring and Peter Ellmark, SITC 9 november 2018

ATOR-1017, a tumor directed Fcγ-receptor cross-linking dependent 4-1BB agonistic antibody

Karin Enell Smith, Anna Rosén, Anna Dahlman, Karin Barchan, Ida Åberg, Doreen Werchau, Mia Thagesson, Niina Veitonmäki, Christina Furebring, Peter Ellmark, SITC 9 november 2018

Potent Tumor-Directed T cell Activation and Tumor Inhibition Induced by a 4-1BB x 5T4 ADAPTIR™ Bispecific Antibody

Michelle Nelson, Gabriele Blahnik-Fagan, Robert Bader, Doreen Werchau, Anneli Nilsson, Lill Ljung, Jeannette Bannink, Danielle Mitchell, Lynda Misher, Catherine McMahan, David Bienvenue, Maria Askmyr, Anna Dahlman, Peter Ellmark, Gabriela Hernandez-Hoyos, Sara Fritzell, SITC 9 november 2018

ATOR-1017; a 4-1BB antibody designed for superior safety/efficacy profile in cancer immunotherapy

Eva Dahlén, Anna Rosén, Adnan Deronic, Karin Barchan, Anna Dahlman, Peter Ellmark, Tina Furebring och Karin Enell Smith., 4th CRI-CIMT-EATI-AACR International Cancer lmmunotherapy Conference 30 september 2018.

The agonistic CD40 antibody improves T cell responses and delays growth of a syngeneic tumor in an ovalbumin vaccination model

Adnan Deronic, Anneli Nilsson, Mia Thagesson, Doreen Werchau, Niina Veitonmäki, Per Norlén, Christina Furebring and Peter Ellmark, World Preclinical Congress June 2018

CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation

Anne Månsson Kvarnhammar, Niina Veitonmäki, Karin Hägerbrand, Mia Thagesson, Doreen Werchau, Kristine Smedenfors, Anna Rosén, Maria Johansson, Per Norlén, Christina Furebring and Peter Ellmark, Poster CIMT 16 May 2018

Tumor Antigen-dependent T Cell Activation And Tumor Localization Induced By A Novel 4-1BB X 5T4 ADAPTIR™ Bispecific Antibody

Sara Fritzell, Doreen Werchau, Maria Askmyr, Niina Veitonmäki, Anneli Nilsson, Adnan Deronic, Mia Thagesson, Anna Säll, Laura von Schantz, Robert Bader, Gabriele Blahnik-Fagan, Michelle Nelson, David Bienvenue, Gabriela Hernandez-Hoyos, Peter Ellmark , Poster CIMT 16 May 2018

Activation of the CD137 Pathway in T cells by a CD137 x 5T4 bispecific ADAPTIR™ Molecule Requires Co-engagement of CD137 and 5T4

Gabriele Blahnik-Fagan, Robert Bader, Jeannette Bannink, Danielle Mitchell, Lynda Misher, Cathy McMahan, David Bienvenue, Laura von Schantz, Eva Lindqvist, Doreen Werchau, Anneli Nilsson, Maria Askmyr, Niina Veitonmäki, Sara Fritzell, Peter Ellmark, Michelle Nelson, and Gabriela Hernandez-Hoyos, Poster AAI 5 May 2018

Design and Generation of Bispecific Antibodies for Immuno-Oncology

von Schantz L, Säll A, Carlsson F, Thorulffsson M, Petersson J, Tsiobanelis K, Nyesiga B, Jansson K, Rosén A, Hägerbrand K, Dahlman A, Månsson-Kvarnhammar A, Veitonmäki N and Furebring C., Poster PEGS 2 May 2018

Screening, Optimization and Characterization of a Novel 4-1BB x 5T4 ADAPTIR™ Bispecific Antibody

von Schantz L, Misher L, Mitchell D, Gruswitz F, Woodruff B, Daugherty M, Aguilar M, Huntington K, Bader R, Blahnik-Fagan G, Säll A, Werchau D, Thagesson M, Nilsson A, Deronic A, Askmyr M, Veitonmäki N, Fritzell S, Ellmark P, Hernandez-Hoyos G and Bienvenue D., Poster PEGS 2 May 2018

CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation

Veitonmäki N, Månsson Kvarnhammar A, Fritzell S, Enell Smith K, Thagesson M, Werchau D, Hägerbrand K, Rosén A, Johansson M, Norlén P, Furebring C, Ellmark P, Poster AACR 17 April 2018

Bispecific antibodies in cancer immunotherapy

Eva Dahlén, Niina Veitonmäki and Per Norlén, Therapeutic advances in vaccines and immunotherapy, 2018, Vol. 6(1) 3–17,